ABSTRACT
The aim of the study is to describe a case of COVID-19 and myocardial infarction in an elderly patient. Material and methods. The analysis of medical documentation (outpatient card of the patient, medical history, postmortem report) was carried out. Studied macro- and micropreparations (staining with hematoxylin and eosin). Results. A 67-year-old patient, from 23.04.2020 to 26.04.2020, was hospitalized with a diagnosis of suspected coronavirus infection (COVID-19). On the background of the treatment, the patient's biological death occurred (26.04.2020). The sectional study revealed signs of bilateral total hemorrhagic pneumonia. The signs of acute transmural myocardial infarction of the anterior wall of the left ventricle were determined. Posthumously, SARS-CoV-2 RNA was detected in the lung tissue by nucleic acid amplification. In the described clinical case, a patient with concomitant cardiovascular diseases, such as arterial hypertension, coronary heart disease, developed complications against the background of COVID-19: hemorrhagic pneumonia and myocardial infarction with a fatal outcome.Copyright © Infectious Diseases: News, Opinions, Training.
ABSTRACT
The SARS-CoV-2 virus has caused one of the most massive pandemics in modern history. The article describes a clinical case of death of a patient who had previously undergone COVID-19. An analysis of the accompanying medical documentation received (patient’s outpatient card, medical history), clinical and morphological analysis (description of macro- and micro-preparations) were carried out using histological and immune-histochemical research methods. Based on the data of medical documentation and the results of postmortem examination it was concluded that the cause of the patient’s death was bilateral organizing pneumonia as a result of pneumonia in combination with ischemic cerebral infarction, complicated by multiple organ failure. © 2021, Media Sphera Publishing Group. All rights reserved.
ABSTRACT
The aim of the study is to describe a case of COVID-19 and myocardial infarction in an elderly patient. Material and methods. The analysis of medical documentation (outpatient card of the patient, medical history, postmortem report) was carried out. Studied macro- and micropreparations (staining with hematoxylin and eosin). Results. A 67-year-old patient, from 23.04.2020 to 26.04.2020, was hospitalized with a diagnosis of suspected coronavirus infection (COVID-19). On the background of the treatment, the patient's biological death occurred (26.04.2020). The sectional study revealed signs of bilateral total hemorrhagic pneumonia. The signs of acute transmural myocardial infarction of the anterior wall of the left ventricle were determined. Posthumously, SARS-CoV-2 RNA was detected in the lung tissue by nucleic acid amplification. In the described clinical case, a patient with concomitant cardiovascular diseases, such as arterial hypertension, coronary heart disease, developed complications against the background of COVID-19: hemorrhagic pneumonia and myocardial infarction with a fatal outcome. © Infectious Diseases: News, Opinions, Training.
ABSTRACT
The global spread of COVID-19 has become a major health problem in the world. The elderly population with hypertension, car-diovascular and cerebrovascular diseases are at risk for COVID-19 infection. Objective. To describe changes in the brain, lungs and heart in COVID-19 against the background of cerebrovascular pathology in an elderly patient. Material and methods. Patient B., 65 years old, was hospitalized in the intensive care unit with a diagnosis of severe COVID-19. Chronic cerebral circulation insufficiency. He was admitted accompanied by an ambulance team with complaints to fever up to 38.3 °C, cough, weakness. From the anamnesis it is known that outpatient treatment with antibacterial drugs was carried out without positive dynamics. In this regard, he was hospitalized for inpatient treatment. Results. Against the background of the ongoing treatment, the patient worsened, and biological death occurred. Pathological and anatomical examination revealed the signs of chronic cerebral ischemia. During histological examination, pronounced dys-trophic, atrophic changes of neurons with loosened neuroglia, perivascular and pericellular edema, areas of erythrocytic slides were observed. In parieto-occipital area of the brain — atrophic, cystic-gliose changes. In cerebral vessels — atherosclerotic plaques, in the stage of atheromatosis and atherocalcinosis, stenosing the lumen up to 60—80%. There were signs of bilateral pol-ysegmental viral pneumonia, with predominant involvement of lower lung lobes. Macroscopic examination of the heart revealed postinfarction cardiosclerosis with erythrocyte sludge. Conclusion. The presence of concomitant pathology weighs down the course of COVID-19 and leads to cerebral edema and acute lung and heart failure. © 2020, Media Sphera Publishing Group. All rights reserved.
ABSTRACT
COVID-19 is an acute respiratory infection caused by SARS-CoV-2 coronavirus causing pneumonia, lesions in the cardiovascular system and other organs, high mortality risk, especially in geriatric patients. Due to the great relevance, this study was aimed at describing the case of severe COVID-19 with development of multiple organ failure. Materials and methods. Available accompanying medical documentation (outpatient charts, medical history) was analyzed. Clinical and morphological analysis was carried out by providing description of macro- and micropreparations;histological methods (hematoxylin and eosin staining, Lee reaction) were used. Results. Female patient K.G., 69 years old, was hospitalized to the therapeutic department diagnosed with coronary heart disease. Acute coronary syndrome with ST segment elevation was made on 04/20/2020. A competing diagnosis: severe community-acquired bilateral multi-segmental pneumonia. The patient's condition was aggravated wile applying therapy followed by biological death occurred. An autopsy revealed bilateral subtotal hemorrhagic pneumonia. Macroscopic lung examination demonstrated "lungs filled with red fluid". In the brain - perivascular and pericellular edema, hyalinosis, blood stasis and sludge, marked dystrophic and necrotic neuronal changes. Cardiomyocyte fragmentation, areas of perivascular sclerosis with inflammatory infiltrates as well as erythrocytic sludge are found in the heart and blood vessels, respectively. A weak positive reaction according to Lee method was observed. Such clinical and morphological case demonstrates along with lung damage involvement of the heart resulting in acute coronary syndrome (morphologically manifested by ischemic myocardial dystrophy) and the brain. Thus, premorbid background in elderly patients results in developing acute pulmonary heart failure, pulmonary and cerebral edema.